Large US trial supports silver diamine fluoride for severe early childhood caries

A phase 3 randomized trial of 830 young children with severe early childhood caries found that 38% silver diamine fluoride arrested 54.0% of eligible cavitated dentin lesions at six months, compared with 22.5% after placebo. The noninvasive treatment showed clinically meaningful efficacy, but about half of the lesions remained active, supporting close monitoring and additional preventive care.